Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery

Systemic administration of antibiotics is an inherently inefficient method for achiev-ing high local tissue concentration, because the vascular system distributes antibioticsuniformly throughout the entire body, only a fraction of the given dose reaches the siteof infection (1). Direct application and local infusion of antibiotics into the surgical woundhas been found to be more effective. However, the rapid absorption of antibiotics fromthe wound site reduces the duration of protection against infection, and local infusion iscumbersome and requires continuous medical attention. A biodegradable dosage form,which could be implanted at the site of surgical incision to release the drug over an ex-tended period of time could be such a method. Extensive work has been done usingpoly D,L-(lactide-co-glycolide) and its derivatives as biodegradable polymer matrices;however, very little work was conducted using non-polymeric materials as biodegrad-able matrices. The implants containing poly D,L-(lactide-co-glycolide), Tween or Spanand tomsulosin hydrochloride were prepared and their release was observed for up to10 days by Mamun