Dioxygenase-catalysed cis-dihydrodiol formation in the carbo- and hetero-cyclic rings of quinolines

Evidence of enzyme-catalysed cis-dihydroxylation in the pyridine (3,4-bond) and benzene rings (5,6- and 7,8-bonds) of quinoline and 2-substituted quinolines is examined in light of the isolation of a heterocyclic cis-diol derivative of 2-quinolone, as a single enantiomer of opposite absolute configuration to that found for the enantiopure carbocyclic cis-diol metabolites from quinolines.