Copper nanoparticle modified carbon electrode for determination of dopamine

a b s t r a c t This paper reports the synthesis and characterization of copper nanoparticles (CuNPs) and applica- tion of copper nanoparticle-modified glassy carbon electrode for the electrochemical determination of dopamine. Electrochemical measurements were performed using differently modified glassy carbon (GC) electrodes. Bare, oxidized before modification and copper nanoparticle-modified glassy carbon elec- trodes (bare-GC, ox-GC and CuNP/GC electrodes, respectively) were characterized by cyclic voltammetry and electrochemical impedance spectroscopy in the presence of redox probes. Atomic force microscopy was used for the visualization of electrode surfaces. The CuNP/GC electrode was found to be suitable for the selective determination of dopamine even in the presence of ascorbic acid, uric acid, and p- acetamidophenol. The observed linear range of CuNP/GC for dopamine was from 0.1 nM to 1.0 M while the detection limit was estimated to be 50 pM. It was demonstrated that here reported glassy carbon elec- trode modified by copper nanoparticles is suitable for the determination of dopamine in real samples such as human blood serum.