RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR

Ziwei Liu,Qianying Yuan,Xuenong Zhang,Chaomei Xiong,Pingping Xue,Jinlan Ruan

RY10-4, a novel anti-tumor compound, exhibited its anti-angiogenesis activity by down-regulation of the HIF-1α and inhibition phosphorylation of AKT and mTOR

2012

Ziwei Liu
Qianying Yuan
Xuenong Zhang
Chaomei Xiong
Pingping Xue
Jinlan Ruan

Purpose To assess the anti-angiogenesis potential and mechanism of RY10-4, a derivative of protoapigenone, which was verified the broad-spectrum anti-tumor activities by previous study.

Keywords:

Protein kinase B
Angiogenesis
RPTOR
PI3K/AKT/mTOR pathway
Phosphorylation
mTORC2
Pharmacology
Downregulation and upregulation
Protoapigenone
Medicine
anti angiogenesis
antitumor activity

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