Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

Thomas Briston,Sian Lewis,Mumta Koglin,Kavita Mistry,Yongchun Shen,Naomi Hartopp,Ryosuke Katsumata,Hironori Fukumoto,Michael R. Duchen,Gyorgy Szabadkai,James Michael Staddon,Malcolm Roberts,Ben Powney

Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

2016

Thomas Briston
Sian Lewis
Mumta Koglin
Kavita Mistry
Yongchun Shen
Naomi Hartopp
Ryosuke Katsumata
Hironori Fukumoto
Michael R. Duchen
Gyorgy Szabadkai
James Michael Staddon
Malcolm Roberts
Ben Powney

Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

Keywords:

Cyclophilin D
Drug discovery
Cell biology
Cryopreservation
High-throughput screening
Mitochondrial permeability transition pore
Molecular biology
Cyclophilin
Mitochondrion
Biology
Membrane potential
ATP synthase
MPTP
Pharmacology
Enzyme

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