IgG антитела к антигенам бактерий, тканей человека, к chlamidia pneumoniae и БТШ60 chlamidia pneumoniae при атеросклерозе

The objective of the present study was to verify evidence suggesting the infectious nature of atherosclerosis by means of immunoenzyme analysis of the sera from the patients (n = 151) presenting with atherosclerosis for the presence of IgG antibodies against various bacterial and tissue antigens. It was found that the majority of the sera (41.7%) contained no antibodies against bacterial and tissue antigens or contained only antibodies against tissue antigens (32,5%). For comparison 72.8% of the sera obtained from control donors (n = 327) contained no IgG antibodies against bacterial and tissue antigens. The study showed that the patients whose sera contained antibodies of both types or only antibodies against bacterial antigens presented with more severe atherosclerosis (4.567 and 4.438 respectively compared with 4.065 and 4.092 in the patients of the two former groups). The severity of atherosclerosis was estimated using the table for the stratification of risk factors of hypertensive disease. The severity of atherosclerosis also correlated with the levels of antibodies against antigens of Chlamidia pneumonia (r = 0.894) and hsp-60 of Chlamydia pneumonia (r = 0.986) that were higher in the sera containing antibodies against a variety of other bacterial antigens. Similar relationships were revealed by the estimation of the percent composition antibodies against chlamydial antigens in each group of patients. The results of the study confirm the role of bacterial (including chlamydial) pathogens in the development and progression of atherosclerosis.