Mucosal Injury of Gastric Corpus by Hemorrhage Reperfusion and Comparison between Preventing and Therapeutic Effect of Salvia Extract F and Cimetidine

To observe the mucosal injury of gastric corpus caused by hemorrhage reperfusion and to compare the anti-mucous injure effect between Salvia extract (SE) and cimetidine (CI) on it. Methods: Model of hemorrhagic shock reperfusion injury was produced by itch method. Wistar rats used in this experiment were randomly divided into three groups, the normal saline (NS) group, the SE group and the CI group. Results: (1)As compared with those in the NS control groupl the index and depth of gastric mucosal lesion in the SE group and the CI group decreased significantly (P0.01), but the difference between the latter two was insignificant (P0.05). (2) Compared with those in the NS group and the CI group, the levels of PGE2, 6- ketoPGF1α. and 6-keto-PGF1α/TXB2 raised and TXB2 lowered obviously in the SE group, while no significant difference was shown between those in the NS group and the CI group. (3)The intracellular calcium content in the SE group and the CI group was markedly higher than that in the NS group (P0.01), but there was insignificant difference between the SE and the CI group (P0.05). Conclusions: Both SE and CI could inhibit the gastric mucosal reperfusion injury, but with different mechanisms. SE could not only enhance the protective factors of gastric mucosa, but also abate the injury factors of it, while CI has the latter only.