Analysis of six tetranucleotide polymorphisms of the X-chromosome in different Spanish regions

We studied 6 X-linked microsatellites in a large group of individuals from five Spanish regions. Those tetranucleotide markers (DXS9895, DXS9898, DXS7130, DXS7131, GATA172D05, and DXS6789) were amplified in two triplex PCR. There was no evidence for statistically significant linkage disequilibrium. There were no significant sex- or region-related differences in allelic frequencies, suggesting that general national databases can be adequate as a reference in X-linked markers. D 2005 Published by Elsevier B.V.