OP-101 The Importance of Contrast Volume and Glomerular Filtration Rate Ratio before and after Transcathater Aortic Valve Implantation

A B The Importance of Contrast Volume and Glomerular Filtration Rate Ratio before and after Transcathater Aortic Valve Implantation. Ilker Gul, Mustafa Zungur, Ahmet Tastan, Faik Fevzi Okur, Ihsan Sami Uyar, Veysel Sahin, Halil Uc, Ahmet Feyzi Abacilar, Mehmet Besir Akpinar, Ertan Damar, Nevzat Uslu, Talat Tavli. Department of Cardiology, Sifa University, Faculty of Medicine, Izmir, Turkey; Department of Cardiovascular Surgery, Sifa University, Faculty of Medicine, Izmir, Turkey; Department of Anesthesiology, Sifa University, Faculty of Medicine, Izmir, Turkey. S T R A C T S Background/Aim: Transcatheter Aortic Valve Implantation (TAVI) is a method that has been applied in severe aortic stenosis (AS) treatment increasingly. Development of Contrast Induced Nephropathy (CIN) after TAVI increases the morbidity and mortality rates. Within the scope of this study, the importance of the rate of contrast medium volume to glomerular filtration rate (CV/GFR) on determining development of CIN and Contrast Medium Volume that could be applied was evaluated. Methods: 72 patients (age; 78.6 11.6, women1⁄438) whom aortic valve replacement was applied with TAVI method within the period between June 2013 and August 2014 were included in the study. CIN was defined as an absolute increase in serum creatinine >0.5 mg/dL or a relative increase >25% within 48-72 hours after TAVI. CIN(þ) patients and CIN (-) patients were classified into first and second groups respectively. Chi-squared test, t-test, Mann-Whitney U test, ROC analysis, univariate and multivariate regression analyzes were applied as statistical analyzes. Results: CIN was detected in 16 patients (22%) within the scope of the study. Baseline creatinine, baseline GFR, Mehran risk score, CV and CV/GFR were determined to be the predictive factors for CIN development. CV/GFR’s being 3.9 was specified to predict CIN development with 71% sensitivity and 80% specificity. Conclusion: CIN may develop due to various reasons after TAVI. In patients whom TAVI is applied CV/GFR proportion may be a guide for preventing development of renal pathologies. Amount of contrast