Metabolic “in-vivo Designing” of Tumors at the Organism and Population Levels under Conditions of Individual Genetic Predisposition. Communication III

Using several populations (ethnic groups) as an example and by means of the statistical analysis of the data available in literature, we theoretically justified the possibility of metabolic “in vivo designing” of tumors in bronchi and lungs, larynx, brain and nervous system, mammary gland, bladder, and liver at the human organism and population levels under conditions of genetically-determined metabolic status of these populations, i.e., the possibility of population-dependent carcinogenesis in the above organs. A comparison of the populations showed that the incidences of cancer (a) in each of the six organs was dissimilar at the different rate of one or other metabolic phenotype and (b) in each of the three organs, larynx, mammary gland, and bladder, it was similar at the same rate of one or other metabolic phenotypes. No population-dependent carcinogenesis in all six or several other organs was observed in the compared populations in the following cases: different cancer incidence in each of six organs at the same rate of one or other metabolic phenotype; similar cancer incidences in each of four organs—larynx, brain and nervous system, mammary gland, and bladder—at a different rate of one or other metabolic phenotypes; and different cancer incidence in organs, other than the mammary gland and liver, in males and females, irrespective of the rate of metabolic phenotype. These data on the incidence rate included no data on chemical carcinogenesis. To prove the population-dependent carcinogenesis in the above-mentioned and other organs, it is necessary to theoretically study and identify the molecular structures responsible for carcinogenesis in tumor cells obtained from representatives of different populations with certain metabolic phenotypes.