More Than the Sum of Its Parts: Single-Cell Transcriptomics Reveals Epidermal Cell States

Compared to mouse models, less is known about human epidermal cell states and differentiation. In this issue of Cell Reports , Cheng et al. (2018) dissect the cell states and heterogeneity in human epidermis with large-scale transcriptomics of 92,889 single epidermal cells from normal and inflamed skin.