Parathyroid Function And Urinary Cyclic 3‘5’ Adenosine Monophosphate

SummaryPatients with hypercalcemie primary hyperparathyroidism excrete more cyclic AMP than normal suhjects: 8.27 ± 0.19 μmoles/24 hr or 9.03 ± 0.92 μmoles/g creatinine.The excretion in hypoparathyroidism is lower than in normal volunteers: 3.07±0.30 μmoles/24 hr or 2.86 ± 0.36 μmoles/g creatinine.Patients with hypercalcemia of non-parathyroid origin excrete less c-AMP than normals: 2.85 ±0.39μmoles/24 hr or 2.73 ±0.39μmoles/g creatinine.The principal clinical use of the determination of urinary c-AMP seems to be the differentiation of hypercalcemia of non-parathyroid origin and hypercalcemia due to PTH-like substances secreted by malignant tumors.