Current progress of gonadotropin-releasing hormone agonist for the luteal phase support

As a clinical routine, luteal phase support (LPS) is recommended in assisted reproductive technique (ART) cycles due to luteal insufficiency (LPD). Administration of gonadotropin-releasing hormone agonist (GnRH-a) has been recently suggested as an alternative for LPS on ART to improve clinical outcomes in recent years. The exact underlying mechanism is still not clear, although it has been hypothesized that GnRH-a either supports the corpus luteum function or stimulates the GnRH-a receptors on the endometrium and embryo. It is necessary to further explore the formulation of GnRH-a, the scope, the minimal effective dosage, the most effective timing, protocol and safety, as well as its exact mechanism. Key words: Gonadotropin-releasing hormone; Assisted reproductive technique; Gonadotropin-releasing hormone agonist; Luteal phase support; Clinical outcomes