Inflammatory Profile in Novel Coronavirus Infection: Biochemical Perspective

The whole world is reeling under the coronavirus disease-2019 (COVID-19) pandemic. It is caused by the novel coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The diagnosis of COVID-19 is based on clinical manifestations, history of exposure, positive findings on chest computerized tomography (CT), and laboratory tests. It has been reported that increased release of pro-inflammatory mediators due to an overactive immune system plays a pivotal role in the pathogenesis of COVID-19. This review provides an insight into the different types of coronavirus strains and inflammatory profile involved in COVID-19 with special emphasis on biomarkers such as procalcitonin, lactate dehydrogenase (LDH), ferritin, D-dimer, and cytokines.