Valproic acid attenuates blood pressure, vascular remodeling and modulates ET-1 expression in L-NAME induced hypertensive rats

Abstract The present study was considered to assess the antihypertensive and antioxidant effect of valproic acid, against Nω- nitro-L arginine methyl ester hydrochloride (L-NAME) induced hypertension in male Wistar rats. Hypertension was prompted in adult male albino rats of the Wistar strain, weighing 180–220 g, by oral administration of the L-NAME (40 mg/kg body weight/day) in drinking water for 4 weeks. The L- NAME hypertensive rats revealed significant ( P P P P P