Reduction of nevirapine-driven HIV mutations by carbamazepine is modulated by CYP3A activity.
2014
Conclusions: The induction of nevirapine elimination reduces HIV-1 resistance mutations, but this effect is modulated by individual CYP3A activity. The study suggests that CYP3A4 activity could be monitored using an endogenous marker and, if needed, boosted to improve clinical endpoints.
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