Visualization of viral populations

M ea n qu as is pe ci es e nt ro py Entropy as a measure of diversity: Frequency distribution entropy Mean entropy of position-wise weighted allel distributions The focus in clinical virology shifts from well-established identification of single nucleotide variants to genome-wide probing of full-length viral RNA strains, called haplotypes. The success of antiretroviral HIV treatment heavily depends on the knowledge of an intra-patient's viral population heterogeneity, because diversity and in particular, low frequency variants affect virulence, immune escape, and drug resistance. We want to visualize such quasispecies to learn more its dynamics.