Design, Synthesis and Antifungal Activity of 3-substituedmethylenethiochroman-4-one Derivatives

Four new 3-substituedmethylenethiochroman-4-one derivatives were prepared from (z)-3-(chlorome- thylene)thiochroman-4-one. They were characterized by analytical and spectral methods. In vitro antifungal activities of these synthesized compounds were evaluated against ten species of fungi, and the results showed that (e)-3-chloromethylene compound exhibited a similar good activity against fungi to (z)-3-chloromethylene compound. (Z)-3-substituedaminomethylene compound also exhibited antifungi activity to some extent.