Variants of Uncertain Significances in Hereditary Breast and Ovarian Cancer

Hereditary breast and ovarian cancer syndrome is a BRCA1- or BRCA2-linked genetic disorder associated with a high risk of developing breast, ovarian, and other cancers. Detection of a BRCA1 or BRCA2 pathogenic variants by genetic testing triggers several clinical management approaches, such as surveillance and prophylactic surgery for healthy carriers, and chemotherapy using poly (ADP-ribose) polymerase (PARP) inhibitors for patients with cancer. Therefore, accurate diagnoses are critical for clinical decision-making and improvement of prognosis.