S,N‐Chelated organotin(IV) compounds containing 6‐phenylpyridazine‐3‐thiolate ligand—structural, antibacterial and antifungal study

A series of tri- and diorganotin(IV) compounds containing potentially chelating S,N-ligand(s) (LSN, where LSN is 6-phenylpyridazine-3-thiolate) were prepared and structurally characterized by multinuclear NMR spectroscopy. X-ray diffraction techniques were used for determination of the structure of compounds containing one [(LSN)Ph2SnCl], two [(n-Bu)2Sn(LSN)2] and the combination of two LSN and one LCN [(LCN)(n-Bu)Sn(LSN)2] (where LCN is {2-[(CH3)2NCH2]C6H4}-) ligands. The coordination number of the tin atom varies from five to seven and is dependent on the number of chelating ligands present. The formation of the five-membered azastanna heterocycle is favored over the formation of four-membered azastannathia heterocycle in compounds containing both types of ligands. The di-n-butyl-substituted compounds are the most efficient ones in inhibition of growth of yeasts, molds and G+ bacteria strains. Copyright © 2011 John Wiley & Sons, Ltd.