Enantioselective Palladium-Catalyzed Arylation of N-Tosylarylimines with Arylboronic Acids Using a Chiral 2,2′-Bipyridine Ligand.

With the aid of an axially chiral 2,2′-bipyridine ligand, we have successfully developed a palladium-catalyzed method for the enantioselective arylation of N-tosylarylimines, furnishing the chiral diarylmethamines with high yields and enantioselectivities under very mild conditions. An exogenous base was avoided and imine hydrolysis was inhibited in this transformation.