Efeitos do extrato de Ginkgo biloba (EGb 761) sobre a atividade motora e a memória em ratos nadadores

2010 
O extrato de Ginkgo biloba (EGb 761) ou exercicio fisico, modificam as funcoes cognitivas e aliviam os sintomas de ansiedade; contudo, estes efeitos devem ser melhor caracterizados. A administracao oral repetida do extrato (40 ou 80 mg/kg/dia) e exercicio de natacao em ratos indicam um aumento de entradas nos bracos fechados no labirinto em cruz elevado (F5,55 = 6.295; p Palavras-chave : Atividade motora. Campo aberto. Ginkgo biloba. Memoria. Labirinto em cruz elevado. Reconhecimento de objetos. ABSTRACT Either ingestion of a Ginkgo biloba proprietary extract (EGb 761) or physical exercise can enhance cognitive functioning and alleviate symptoms of anxiety; however, their combined effects have yet to be characterized. Rats subjected to repeated oral administration of the extract (40 or 80 mg/kg/day) and swimming exercise exhibited an increased number of closed-arm entries in the elevated plus-maze and decreased immobility in the open field, suggesting an increase in motor activity. In addition, the exercise of swimming increased the exploration of the open field and chronic treatment with EGb 761 could cancel this effect; this indicates interaction between EGb 761 and swimming exercise, which may show a common neurobiological substrate, capable of reducing exploratory activity in swimming rats. Analysis of behavior in the object-recognition test showed that rats subjected to swimming exercise and/or treatment with EGb 761, during tests of 24 hours, spent more time exploring novel objects than familiar ones. These results show that EGb 761 and/or physical exercise have powerful effects on long-term memory. However, the proposed anxiolytic characteristics of EGb 76 and swimming exercise may be questioned. Keywords : Ginkgo biloba. Memory. Motor activity. Elevated plus-maze. Object recognition. Open field.
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