Topical Oxygen Emulsion: A Novel Wound Therapy

2007 
Design: Oxygen is a required substance for various aspects of wound repair, and increased oxygen tension in a wound has been shown to stimulate phagocytosis and to reduce the incidence of wound infection. Second-degree burns and partial-thickness wounds were created on the backs of specific pathogen-free pigs. Wounds were then randomly assigned to 1 of the following treatment groups: TOE, TOE vehicle, or air-exposed control. Main Outcome Measure: Wounds were assessed for complete epithelialization using a salt-split technique. Results: The TOE was able to significantly (P=.001) enhance the rate of epithelialization compared with both vehicle and untreated control. These data suggest that topical oxygen may be beneficial for acute and burn wounds. Conclusions: The results obtained from this doubleblind,control,invivostudydemonstratethatTOEcansignificantly enhance the rate of epithelialization of partialthickness excisional wounds and second-degree burns. These findings could have considerable clinical implications for patients with surgical and burn wounds by providing functional skin at an earlier date to act as a barrier against environmental factors, such as bacteria invasion. Othertypesofwoundsmayalsobenefitfromthistherapy (eg, chronic wounds and surgical incisions). Additional studies, including clinical studies, are warranted. Arch Dermatol. 2007;143(10):1252-1256
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