Indicators of Oxidative Stress in Aged Fischer 344 Rats: Potential for Neurotrophic Treatment

The etiology(ies) of the major human neurodegenerative diseases is completely unknown. Eisen and Caine1 have discussed the pathologic similarities of amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Alzheimer’s disease (AD), and hypothesized that these neurodegenerative diseases share a common etiology. We are pursuing two hypotheses concerning the cause and treatment of these neurodegenerative disorders, two hypotheses that are not mutually exclusive.