Expression of Na + /myo-inositol cotransporter mRNA in normal and hypertonic stress rat eyes
1996
Abstract We studied the localization of Na + / myo -inositol cotransporter (SMIT) mRNA in normal and hypertonic stress rat eyes by in situ hybridization histochemistry using cRNA probes. SMIT mRNA signals were observed in the iris-ciliary body, the lens epithelial cells, and the ganglion cell layer and the inner nuclear layer of the retina. There was a rapid increase on SMIT mRNA in the retina of hypertonic stress rats compared with control rats. These findings suggest that Na + / myo -inositol cotransporter gene expression is osmotically regulated in vivo to protect retinal neuronal function against hypertonic stress.
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