Editor's Note Series on Exercise in Cardiovascular Disease

For more than a half century, exercise testing has remained a readily available and reliableclinical tool to evaluate patients with known or suspected cardiovascular disease. Yet, datacontinue to emerge regarding novel applications of this durable technology. Exercise, however,has taken on a new role in contemporary clinical cardiology for its therapeutic benefits in both theprimary and secondary prevention of cardiovascular disease. While it has long been recognizedthat exercise and physical activity confer health, the data that support this observation are nowrobust and far-reaching. Understanding the mechanisms by which exercise yields its myriad ofbenefits has become a prolific area of research, the findings of which tell an interesting andevolving story that spans from molecular interactions to integrated physiological systems.Accordingly, in this