A composition and method for preparing ibuprofen injection
2013
The invention relates to an ibuprofen injection. The injection consists of an active component ibuprofen and a cosolvent arginine, and is characterized in that the molar ratio of ibuprofen to arginine is 1:1.08-1.12, pH conditioning agents are not used, the amount and kind of accessories during injection preparation are reduced, irritation is low and security is higher. The prepared ibuprofen injection is substantially improved in resistance of high temperature and hard light; not only insoluble particles are obviously minimized, but also the compatibility problems of the injection with common salt and glucose injections are solved; and the product quality stability is substantially improved, and clinic compatibility demands are satisfied. Also, the invention provides a preparation method which is simple in technology and suitable for industrialized production.
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