Validation of a software-based clinical trial matching platform for oncology using comprehensive clinical information.

e18589Background: Despite the critical need for cancer patients to participate in clinical trials, only 3% of US cancer patients actually do so, and 40-60% of oncology clinical trials fail to recruit enough patients to meet their statistical endpoints (1). One of the fundamental causes of this issue is that traditional manual eligibility determination is inefficient and costly. To address this, Driver has developed a scalable software platform that accelerates clinical trial eligibility screening for individual cancer patients and conducted a validation of the platform’s clinical performance with the NCI Center for Cancer Research (CCR). Methods: Medical records from 21 metastatic prostate cancer patients who were enrolled on a therapeutic clinical trial at the CCR within the last 5 years were processed by the Driver platform. The CCR provided Driver with all relevant retrospective clinical data available before these patients were screened. Eligibility results produced by Driver were compared to the tria...