Glycemic Control and Variability of Diabetes Secondary to Total Pancreatectomy Assessed by Continuous Glucose Monitoring.

CONTEXT The extent of the glycemic variability in diabetes secondary to total pancreatectomy is not fully understood. OBJECTIVE To evaluate glycemic variability in totally pancreatectomized (PX) patients and compare it to glycemic variability in HbA1c-matched patients with long-standing type 1 diabetes (T1D). DESIGN a case-control study was performed. SETTING Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen. PATIENTS OR OTHER PARTICIPANTS Ten PX patients (mean(SEM): age 64.3(9.8) years; Body Mass Index (BMI) 34.4(5.0) kg/m 2; duration of diabetes 3(2.8) years), 10 HbA1c-matched patients with T1D (63.9(8.6) years; 24.6(3.1) kg/m 2; 22(4) years) and 10 gender, age and BMI-matched healthy controls (CTRLs), All patients were managed on multiple daily injections of insulin. INTERVENTION Continuous glucose monitoring (CGM) (Medtronic MiniMed iPro 2) during twelve consecutive days. MAIN OUTCOME MEASURES Glycemic Variability. RESULTS HbA1c levels were similar in the PX group and the T1D group. The PX group had greater CONGA60min compared to the T1D group (mean(SEM): 9.5(0.3) vs 8.3(0.2) mmol/L, P<0.003) and mean plasma glucose values were higher in the PX group (10.6(0.9) vs 9.0(0.9) mmol/L, P<0.001) while CVpg and SDpg, respectively, were similar in the two groups. Time spent below range was not different between the PX and the T1D group (2.3(0.8) vs 4.5(0.8) %, P=0.065) while time spent above range was higher in the PX group (51.4(3.3) vs 37.6(1.9) %, P<0.001). CONCLUSIONS CGM-assessed glycemic variability showed higher CONGA60 min and time spent above range in our PX patients compared with HbA1c-matched T1D patients.