Impact of liver volume on polycystic liver disease-related symptoms and quality of life

BackgroundSymptoms in polycystic liver disease (PLD) are thought to be caused by compression of organs and structures by the enlarged liver.AimThe aim of this article is to assess the impact of liver volume on symptoms and quality of life (QoL) in PLD.MethodsWe included PLD patients from two prospective studies that used the PLD-questionnaire (PLD-Q) for symptom assessment. QoL was assessed through SF-36, summarized in a physical (PCS) and mental (MCS) component score. Liver volume was correlated with PLD-Q total scores. Patients were classified based on height-corrected liver volume in mild ( 3200 ml) disease. PLD-Q and QoL (PCS and MCS) scores were compared across disease stages.ResultsWe included 82 of 131 patients from the original studies (disease stages; mild n = 26, moderate n = 33, and severe n = 23). Patients with larger liver volume reported higher symptom burden (r = 0.516, p < 0.001). Symptom scores increased with disease progression, except for ...