Alokicenones A-H, eight tetrahydroanthracenes from the mangrove-derived Streptomyces sp. HN-A101

Abstract Alokicenones A-H ( 1–8 ), eight new tetrahydroanthracenes and one known okicenone ( 9 ) were identified from the secondary metabolites of mangrove-derived Streptomyces sp. HN-A101. Their structures were elucidated by HRESIMS and NMR spectroscopic data. The absolute configurations of them were determined by the calculated and experimental ECD curves. Compounds 1–2 and 9 showed moderate cytotoxicity against HCT116 and SW620 cancer cell lines with IC 50 values from 0.63 to 7.73  μ M. In addition, compounds 1 – 3 and 7 – 9 also exhibited inhibitory activities against ROCK2 or BRD4.