Haplotype analysis of aldosterone synthase gene (CYP11B2) polymorphisms shows association with essential hypertension

ObjectiveThe CYP11B2 locus is an important candidate region in essential hypertension (HT). We therefore investigated CYP11B2 polymorphisms T−344C, T4986C and A6547G for association with essential HT. This included haplotype analysis and measurement of plasma aldosterone levels.MethodsThe three sing