P40: The prevalence of glomerular hyperfiltration in subjects with type 2 diabetes

Objective: The onset of type 2 diabetes (T2DM) is not readily identifiable, so a patient newly diagnosed with type 2 diabetes may have renal disease from glomerular hyperfiltration (GH) to advanced diabetic nephropathy. The aim of this study was to compare the prevalence of GH in type 2 diabetic subjects with that in subjects who had not been diagnosed with diabetes and to examine whether there was an association between GH and hemoglobin A1c (HbA1c) levels in subjects with prediabetes Methods: The study subjects (n = 17667) were individuals who participated in the fourth, fifth and sixth annual Korean National Health Examination and Nutrition Survey (KNHANES). The GFR of each participant was estimated from the serum creatinine (SCr) value using the Modification of Diet in Renal Disease equation (MDRD). GH was defined as an estimated glomerular filtration rate (eGFR) above 120 mL/min/1.73m2 Results: Among a total of 17667 people aged 20~80 years who were enrolled into the study, 2625 people had been diagnosed with T2DM. The prevalence of GH in subjects with T2DM significantly increased when compared with that in people without diabetes (odds ratios: 1.853, 95% confidential interval: 1.406-2.442). HbA1c levels in subjects with prediabetes were associated with GH (odds ratio: 1.096, 95% confidential interval: 1.011-1.175) Conclusion: We conformed that the prevalence of GH in subjects with T2DM increased when compared with that in subjects without diabetes and there was significantly the association between HbA1c levels in prediabetic subjects and GH. Therefore, it may be suggested that the functioning of kidneys should be monitored in subjects with prediabetes.