Radical-Mediated Alkoxypolyhaloalkylation of Styrenes with Polyhaloalkanes and Alcohols via C(sp3)-H Bond Cleavage
2021
We have developed a new radical-mediated alkoxypolyhaloalkylation of styrenes with polychloroalkanes and alcohols for the facile synthesis of complex polyhaloalkanes. 4-Methoxybenzenediazonium tetrafluoroborate is a good radical initiator for this transformation. This protocol is well applied to the late-stage functionalization of complex molecules, including vitamin E, estrone and cholesterol derivatives.
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