Highly Chemoselective and Enantiospecific Suzuki–Miyaura Cross-Couplings of Benzylic Organoboronic Esters
2013
The use of potassium carbonate in addition to silver oxide is shown to increase the enantiospecificity of the Suzuki–Miyaura cross-coupling reaction of chiral secondary benzylic boronic esters. From mechanistic studies, it is shown that the reaction is compatible with Mizoroki–Heck coupling partners, even when they are present in considerable excess. This unique chemoselectivity provides the opportunity to carry out sequential reactions.
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