Correlation of adiponectin, monocyte chemoattractant protein - 1, and endothelial function to vascular remodeling in coronary in - stent restenosis

Objective To investigate the correlation between vascular remodeling index (RI) and serum adiponectin, plasma monocyte chemoattractant protein-1 (MCP-1), endothelial function and evaluate the mechanism of coronary in-stent restenosis. Methods RI 6 months after percutaneous coronary intervention (PCI), serum adiponectin, plasma MCP-1 and flow-mediated dilation (FMD) before and 3 days,6 months after PCI were measured in 30 patients with and 30 without coronary in-stent restenosis. Results Compared with patients without restenosis and those with restenosis before PCI, the patients with coronary in-stent restenosis showed significantly increased plasma MCP-1 3 days and 6 months after PCI ( P <0.05) and reduced RI 6 months after PCI, serum adiponectin and FMD 3 days and 6 months after PCI ( P <0.05). RI was positively correlated to serum adiponectin and FMD and inversely to MCP-1. Conclusion The occurrence of coronary in-stent restenosis is the result of the interrelations between multiple factors.