New Bioactive Bromotyrosine-Derived Alkaloid from a Marine Sponge Aplysinella sp

A new bromotyrosine-derived alkaloid, (+)-aplysinillin ( 1), together with seven known compounds, was isolated from the crude organic extract of the marine sponge APLYSINELLA sp. collected from the Federated States of Micronesia. The structure of 1 was deduced by NMR and mass spectral techniques. Compounds 1 - 8 were evaluated for their inhibitory activity with the hyphae formation inhibition assay in STREPTOMYCES 85E. Compounds 1 and 8 exhibited antiproliferative activities against the human breast adenocarcinoma cancer cell line MCF-7.