Abstract 131: Insulin Regulated Aminopeptidase Inhibitors are More Effective Than the ACE Inhibitor, Perindopril in Preventing Unilateral Ureteral Obstruction-Induced Renal Fibrosis in Mice

Sharenya Chelvaretnam,Matthew Shen,Simon J. Mountford,Philip E. Thompson,Siew Yeen Chai,Robert E Widdop,Chrishan S. Samuel,Tracey Gaspari

Abstract 131: Insulin Regulated Aminopeptidase Inhibitors are More Effective Than the ACE Inhibitor, Perindopril in Preventing Unilateral Ureteral Obstruction-Induced Renal Fibrosis in Mice

2019

Sharenya Chelvaretnam
Matthew Shen
Simon J. Mountford
Philip E. Thompson
Siew Yeen Chai
Robert E Widdop
Chrishan S. Samuel
Tracey Gaspari

New strategies are needed to combat pathological organ fibrosis that leads to end stage organ failure. We have identified the enzyme insulin regulated aminopeptidase (IRAP) as one such promising ne...

Keywords:

Internal medicine
Diabetes mellitus
Endocrinology
Aminopeptidase
Perindopril
Insulin
Fibrosis
ACE inhibitor
Medicine
Kidney
renal fibrosis
Enzyme
Pathological

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