Hormonal component of the postprandial motility response of the proximal stomach in dogs

: The motility of a proximal gastric pouch, that has been extinsically denervated by autotransplantation, has been studied in 4 dogs. In the same time, the electrical activity of the duodenum was recorded with AgAgCl electrodes. Recordings were made in the fasting state and after oral administration of 250 ml NaCl 154 mM solutions containing 15 kcal/kg of either glucose, peptides or lipids, or 3 X 5 kcal/kg of a mixture of these three nutrients. The results showed, in the fasting state, that a cyclic activity took place in the denervated gastric pouch corresponding to the myoelectric complex observed at the same time in the duodenum. After feeding the dogs with any nutrient solution, we observed: 1) a decrease in pouch pressure; 2) an interruption of the cyclic activity in both the pouch and duodenum. A fasting motility resumed simultaneously in both the pouch and duodenum. These results indicate that hormonal agents are involved in the motility of the proximal stomach as well as in the postprandial interruption of the myoelectric complex.