Organocatalyzed Cascade Reactions of Cyclic β-Enamino Esters and α,β-Unsaturated Aldehydes Leading to Indoloquinolizidines and Benzoquinolizidines.

Organocatalyzed cascade reactions between cyclic β-enamino esters and α,β-unsaturated aldehydes have been developed. They provide highly substituted indolo[2,3-a]quinolizidines and benzo[a]quinolizidines in moderate to good yields and with good to excellent enantioselectivities. Both aromatic and aliphatic α,β-unsaturated aldehydes react readily with enamino esters to furnish the desired products.