Asymmetric Total Synthesis of ()-Gymnasterkoreayne G

E-mail: dyshin21@gachon.ac.krReceived January 28, 2012, Accepted March 5, 2012Key Words : Total synthesis, Asymmetric, Gymnasterkoreayne, Chemopreventive, Chiral resolutionNaturally occurring diynes are found as metabolites in avariety of fungi, higher plants, and marine sponges; theirpharmacological properties, including cytotoxic, antimicro-bial, and enzyme inhibitory activities, attract special atten-tion in the realm of medicinal chemistry.