Indolent Cutaneous T-Cell Lymphomas

Primary cutaneous lymphomas are a heterogeneous group of non-Hodgkin lymphomas that present in the skin with no evidence of extracutaneous disease at the time of diagnosis. Within this group, the majority is derived from T-cells. The different types of cutaneous lymphomas are defined by various clinical manifestations, histological patterns, and immunophenotypic markers. In contrast to the nodal non-Hodgkin lymphomas, primary cutaneous T-cell lymphomas (CTCL) usually represent an indolent disease group and therefore require mostly skin-directed therapies. However, at later stages, certain subtypes run a more aggressive course.