Indole-Glucosides as Novel Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors. Part 2.
2006
A series of indole-O-glucosides and C-glucosides was synthesized and evaluated in SGLT1 and SGLT2 cell-based functional assays. Compounds 2a and 2o were identified as potent SGLT2 inhibitors and screened in ZDF rats.
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