[Long-term study of 150 mg. Bi-Profenid in patients followed at the Department of Rheumatology of Cochin Hospital].

: The effectiveness and tolerance of Bi-Profenid 150 mg (two tablets a day) was evaluated in 37 patients under long-term treatment by retrospective analysis of case records. Mean duration of therapy was 15.5 months. Over this period improvement in the usual surveillance criteria was recorded. In 6 patients the "therapeutic follow-up test" allowed to decrease dosage to one tablet a day. Conversely, attempts at discontinuing the drug were followed by recurrence of pain. Tolerance was evaluated as excellent in 89% of cases and the only recorded side-effects were gastrointestinal.