Pemetrexed disodium aseptic powder injection and preparation method thereof

The invention belongs to the technical field of medicinal preparations and in particular relates to pemetrexed disodium aseptic powder injection and a preparation method thereof. The preparation method comprises the following steps: dissolving pemetrexed disodium in water to prepare pemetrexed disodium solution, aseptically filtering the pemetrexed disodium solution to obtain medicinal solution A; carrying out aseptic filtration on crystallization solvent; adding the crystallization solvent into the medicinal solution A in a stirring manner under the aseptic condition to separate out pemetrexed disodium crystals; filtering and drying under reduced pressure at the normal temperature to obtain an aseptic pemetrexed disodium raw material; distilling the filtrate to recycle the crystallization solvent; subpackaging the aseptic raw material according to the dosage to prepare the pemetrexed disodium aseptic powder injection. Compared with the prior art, the preparation method of the pemetrexed disodium aseptic powder injection has the advantages that the preparation processes are carried out at the normal temperature, the process is simple, the product quality is stable, the energy consumption of the ordinary freeze-dried powder injection is reduced, and the industrial production is liable to implementation.