[Association analysis between attention-deficit hyperactivity disorder and Val158Met polymorphism of catechol-O-methyltransferase gene].

Objective To investigate the association between attention-deficit hyperactivity disorder(ADHD) in Han Chinese children and Val158 Met polymorphism of catechol-O-methyltransferase(COMT) gene caused by the missense mutation of G158A in exon 4. Methods By using polymerase chain reaction-restriction fragment length polymorphisms the Val158 Met polymorphism of COMT gene was tested in 117 children with the diagnosis of ADHD as defined by DSM-Ⅳ and in 105 healthy controls living in Shanghai.Results The frequencies of A allele were 25.21% and 23.81% in the ADHD group and the health controls respectively, which showed no significant difference between the two groups (χ2=0.5197, P0.05). There was also no significant difference in the distribution of all genotypes of COMT gene between the ADHD patients and the controls (P0.05).Conclusion It was suggested that for the Han Chinese children with ADHD in this study,there was no association between ADHD and Val158Met polymorphism of COMT gene.