Etiology and drug resistance analysis in acute exacerbation of chronic obstructive pulmonary disease.

Objective:To study the characteristics of the etiology and drug resistance in acute exacerbation of chronic obstructive pulmonary disease patients,to provide a favorable clinical basis for rational drug use. Methods:563 cases diagnosed as AECOPD patients from January 2008 to January 2009 in Respiratory and Geriatric Medicine departments at our hospital were retrospectively analyzed. Results:of their sputum samples for culture and sensitivity test were collected and analyzed. Results 205 cases(36.41%) out of 563 cases of patients were tested positive,among which 46 cases(22.44%) were detected with G+ bacteria,119 with G-bacteria(58.05%) ,40 with fungal(19.51%) . Most of the G+ bacteria infection were Staphylococcus aurous(14 cases) ,followed by Staphylococcus epidermidis and Streptococcus viridians;Most of the G-bacteria infection were Pseudomonas(37 cases) ,followed by Klebsiella. Most of the fungal infection were Candida albicans(20 cases) . G-bacteria showed a strong drug resistance to ampicillin,piperacillin,cefazolin and cotrimoxazole,and a strong sensitivity to imipenem and β-lactamase inhibitor. Staphylococcus aureus were seriously resistant to multiple antibiotics and sensitive to vancomycin and imipenem. Fungal drug sensitivity test showed that 50.81% of them were sensitive to fluconazole,30.12% sensitive to Itraconazole-,30.83% of them sensitive to ketoconazole,and 10.74% of them sensitive to 5-fluorocytosine. Conclusion:G-bacteria in AECOPD patients are predominant. There is a growing trend in fungal infections. The pathogenic bacteria showed a multi-drug resistance.