Machine learning technology in the application of genome analysis: A systematic review

Abstract Machine learning (ML) is a powerful technique to tackle many problems in data mining and predictive analytics. We believe that ML will be of considerable potentials in the field of bioinformatics since the high-throughput technology is producing ever increasing biological data. In this review, we summarized major ML algorithms and conditions that must be paid attention to when applying these algorithms to genomic problems in details and we provided a list of examples from different perspectives and data analysis challenges at present.