Surface arming magnetic nanoparticles with amine N-halamines as recyclable antibacterial agents: Construction and evaluation.
2016
Abstract Magnetic recyclable antibacterial nanomaterials, i.e. , magnetic amine N -halamine nanoparticles (Fe 3 O 4 @SiO 2 /CTMP NPs), were constructed by arming magnetic silica nanoparticles (Fe 3 O 4 @SiO 2 NPs) with amine N -halamine (CTMP). Magnetic iron oxide nanoparticles were encapsulated into silica layers followed by anchoring antibacterial amine N -halamines to give magnetic/antibacterial bi-functional agents with core-shell structure. Since the presence of Fe 3 O 4 NPs in core, the products offer super-paramagnetic behavior, which made them separable magnetically after the antibacterial behavior. Their sterilizing effect on bacterial strain was evaluated using Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) as model bacteria via the plate counting technique, zone of inhibition study, and time kill assay. Antibacterial mechanism study illustrated that the products integrate both the contact mechanism and the release mechanism for attacking bacteria. The significant effect of oxidative chlorine content and concentration of the products on antibiotic action were confirmed. Thanks to the magnetic property, the potential recyclability of the products was achieved. Most significantly, the products retain effective antibacterial action even after five cycles. These findings revealed that the products Fe 3 O 4 @SiO 2 /CTMP NPs have promising applications in the antibacterial fields.
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