Hitit Index to distinguish patients with and without Crimean-Congo hemorrhagic fever

Abstract Crimean-Congo hemorrhagic fever (CCHF) is fatal. Therefore, it is very important to use an inexpensive, easily accessible, quick and accurate screening index based on clinical signs and laboratory parameters to identify patients suspected of having CCHF. Laboratory test results on the day of hospitalization for 268 inpatients suspected of having CCHF were used to calculate the laboratory section of the Hitit Index, while 65 of these were also monitored daily during their hospital stay to develop the clinical section of the Hitit Index. Two-hundred CCHF-negative outpatients were also evaluated. One-hundred and forty-nine inpatients were CCHF-positive and 119 inpatients were CCHF-negative. The Hitit Index is 5.6 − (5.3*lymphocyte) − (0.02*fibrinogen) − (12*direct bilirubin) + (0.04*AST) + (0.32*hematocrit) − (0.5*neutrophil) − (0.07*CKD-EPI) − (0.001*CK) ± conjunctival hyperemia (+1.5 in conjunctival hyperemia presence and −1.5 in conjunctival hyperemia absence). In 65 inpatients monitored daily, Hitit Index results for CCHF-positive and negative inpatients were 6.10(1.90–12.30) and -5.35(−8.83– −1.95), while CCHF-negative outpatients were −10.99(−15.64– −6.95) ( P Management of patients living in endemic regions suspected of having CCHF could be achieved within minutes using the Hitit Index. Patients with Hitit Index less than zero can be monitored as outpatients, while patients with Hitit Index results above zero must be hospitalized in infectious diseases wards. This study was not registered since it was retrospective.